Aim of present study was to evaluate the in-vitro drug release kinetic of 4 mg tablets containing non-micronized and micronized glimepiride by using micronization technology. Several tablet formulations were designed, optimized, developed and characterized. Best optimized tablet formulation was selected for further studies. Two batches of the tablets were prepared, one for non-micronized and other for micronized glimepiride 4 mg tablets. These tablets were subjected to evaluation for micromeritics, compatibility, physical properties viz. hardness, thickness, friability, weight variation, uniformity of content and dissolution studies. Total experiment was carried out quite methodically and scientifically. Micromeritics properties of powder blend of both non-micronized and micronized glimepiride 4 mg tablets for direct compression were found within permissible limits for successful compression. Also, it was found that the physical properties of non-micronized and micronized glimepiride 4 mg tablets such as hardness, thickness, friability, weight variation and content uniformity all were found within the Pharmacopoeial limit. No drug-excipients interaction was found and it was confirmed by infra-red spectroscopy which indicates the mutual compatibility. Finally, accelerated stability study was performed and results were compared between the two batches. Results of this studies revealed that, micronized tablet formulation of glimepiride 4 mg released much drug content i.e. 102.74 ± 5.13 % compared to non-micronized tablets which had released just 59.61 ± 8.64 %. Based on the above studies, it can be concluded that micronization of a poorly soluble drug such as glimepiride is an important technique to enhance the rate of dissolution.
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